Overview
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 45 Reviews
8
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
0
Vitamin B12 ineffective for CFS
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
Read More
8
We investigated the use of vitamin B12 nasal drops in adults with chronic fatigue syndrome (CFS) over three months. A total of 51 patients participated, and we measured their vitamin B12 levels alongside physical activity and fatigue scores.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Read More
8
We evaluated the impact of B12 injections combined with folic acid on patients with chronic fatigue syndrome, also known as myalgic encephalomyelitis (ME). In our survey of 38 patients, we identified two groups based on their response: Good and Mild responders. Good responders received more frequent and higher doses of B12, leading to significant improvements in their symptoms.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
Read More
Most Useful Reviews
8
Increased energy levels
211 people found this helpful
Vitamin B12 is crucial for the body. I take it for my parents as they experience chronic fatigue syndrome. Since starting the supplements, they feel more active and less lethargic. We take it in courses and follow a break. The tablets are tiny and slightly sour. For optimal absorption, they need to dissolve completely.
Read More
8
Improved vitality
118 people found this helpful
Excellent! Vitamin B12 is essential for the body. I give it to my parents due to their chronic fatigue syndrome. They now feel more cheerful and lively, with reduced lethargy and fatigue. We take it in courses with breaks. The small sour tablets should fully dissolve for maximum effect.
Read More
10
Nervous system support
13 people found this helpful
This is an effective remedy for my chronic fatigue syndrome. The active form of vitamin B12 supports brain function and overall nervous system health. It’s essential for combating stress, fatigue, and insomnia. I also take it with folic acid for better results.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
- All Researches
8
We investigated the use of vitamin B12 nasal drops in adults with chronic fatigue syndrome (CFS) over three months. A total of 51 patients participated, and we measured their vitamin B12 levels alongside physical activity and fatigue scores.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Read More
8
We evaluated the impact of B12 injections combined with folic acid on patients with chronic fatigue syndrome, also known as myalgic encephalomyelitis (ME). In our survey of 38 patients, we identified two groups based on their response: Good and Mild responders. Good responders received more frequent and higher doses of B12, leading to significant improvements in their symptoms.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
Read More
8
We recently came across an intriguing study that highlighted the potential benefits of a combination therapy involving lofepramine, L-phenylalanine, and vitamin B12 for patients suffering from multiple sclerosis (MS). Conducted as a randomized, placebo-controlled double-blind trial, the research aimed to evaluate how this combination could help alleviate various symptoms associated with MS and chronic pain.
While this study did address the role of vitamin B12, it was examined alongside lofepramine and phenylalanine. This makes it challenging for us to pinpoint the specific impact of vitamin B12 in the context of chronic fatigue syndrome on its own. The treatment showed effectiveness in improving symptoms within just two to four weeks, but due to the combination of treatments, we need more focused studies to assess vitamin B12's distinct role.
Overall, it's exciting to see a potential link between this therapy and symptom relief, yet we must remain cautious about attributing the benefits solely to vitamin B12, given the blended approach of the therapy used in the trial.
While this study did address the role of vitamin B12, it was examined alongside lofepramine and phenylalanine. This makes it challenging for us to pinpoint the specific impact of vitamin B12 in the context of chronic fatigue syndrome on its own. The treatment showed effectiveness in improving symptoms within just two to four weeks, but due to the combination of treatments, we need more focused studies to assess vitamin B12's distinct role.
Overall, it's exciting to see a potential link between this therapy and symptom relief, yet we must remain cautious about attributing the benefits solely to vitamin B12, given the blended approach of the therapy used in the trial.
Read More
7
Vitamin B12 shows unclear benefits
We explored the effect of vitamin B12 on individuals diagnosed with chronic fatigue syndrome. The study focused on assessing how this vitamin might alleviate the symptoms associated with the condition. While many participants underwent concurrent treatments, which complicates isolating vitamin B12's specific impact, the research still provides insightful data.
Participants were monitored to see if vitamin B12 made a notable difference in fatigue levels and overall well-being. However, it appeared that the results were not overwhelmingly positive. The concurrent treatments among participants diluted our ability to assess the true effectiveness of vitamin B12 on its own, leading to an inconclusive outcome.
While we acknowledge the interest in vitamin B12 as a potential remedy for chronic fatigue syndrome, the findings suggest no significant benefits can be attributed to it directly. More focused research might be necessary to fully understand how—or if—vitamin B12 can support those dealing with this challenging syndrome.
Participants were monitored to see if vitamin B12 made a notable difference in fatigue levels and overall well-being. However, it appeared that the results were not overwhelmingly positive. The concurrent treatments among participants diluted our ability to assess the true effectiveness of vitamin B12 on its own, leading to an inconclusive outcome.
While we acknowledge the interest in vitamin B12 as a potential remedy for chronic fatigue syndrome, the findings suggest no significant benefits can be attributed to it directly. More focused research might be necessary to fully understand how—or if—vitamin B12 can support those dealing with this challenging syndrome.
Read More
7
We observed that a group of twelve outpatients, all women diagnosed with both fibromyalgia and chronic fatigue syndrome, participated in a study focused on understanding the role of vitamin B12 in their condition. While most of their blood lab results were normal, one significant finding stood out: all patients had elevated levels of homocysteine in their cerebrospinal fluid.
The study found a noteworthy link between these increased homocysteine levels and the degree of fatigue experienced by the patients. Moreover, low levels of vitamin B12 in the cerebrospinal fluid were correlated with feelings of fatigue, suggesting that vitamin B12 might play a vital role in how these patients feel day-to-day.
The researchers concluded that the elevation of homocysteine in the central nervous system could be indicative of fibromyalgia and chronic fatigue syndrome. They suggested that a deficiency in vitamin B12 might hinder the body's ability to regulate homocysteine, contributing to the symptoms of fatigue these patients experience. However, while vitamin B12 is shown to be important in this context, the study does not specifically isolate its effects from other contributing factors or treatments.
The study found a noteworthy link between these increased homocysteine levels and the degree of fatigue experienced by the patients. Moreover, low levels of vitamin B12 in the cerebrospinal fluid were correlated with feelings of fatigue, suggesting that vitamin B12 might play a vital role in how these patients feel day-to-day.
The researchers concluded that the elevation of homocysteine in the central nervous system could be indicative of fibromyalgia and chronic fatigue syndrome. They suggested that a deficiency in vitamin B12 might hinder the body's ability to regulate homocysteine, contributing to the symptoms of fatigue these patients experience. However, while vitamin B12 is shown to be important in this context, the study does not specifically isolate its effects from other contributing factors or treatments.
Read More
User Reviews
USERS' SCORE
Good
Based on 45 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
8
Increased energy levels
211 people found this helpful
Vitamin B12 is crucial for the body. I take it for my parents as they experience chronic fatigue syndrome. Since starting the supplements, they feel more active and less lethargic. We take it in courses and follow a break. The tablets are tiny and slightly sour. For optimal absorption, they need to dissolve completely.
Read More
8
Improved vitality
118 people found this helpful
Excellent! Vitamin B12 is essential for the body. I give it to my parents due to their chronic fatigue syndrome. They now feel more cheerful and lively, with reduced lethargy and fatigue. We take it in courses with breaks. The small sour tablets should fully dissolve for maximum effect.
Read More
10
Nervous system support
13 people found this helpful
This is an effective remedy for my chronic fatigue syndrome. The active form of vitamin B12 supports brain function and overall nervous system health. It’s essential for combating stress, fatigue, and insomnia. I also take it with folic acid for better results.
Read More
9
Numbness improvement
10 people found this helpful
After developing carpal tunnel syndrome, I discovered this vitamin B12 supplement. Within a week, my fingertip numbness lessened, and after a month, it mostly subsided. I attribute this improvement to the supplement, even though my chronic fatigue syndrome symptoms persist.
Read More
10
Enhances overall health
4 people found this helpful
I've been using B12 for months, and it has significantly improved my energy levels, eliminating persistent drowsiness often associated with chronic fatigue syndrome. I've also noticed enhancements in mood and cognitive function, which has made a meaningful difference in my daily life.
Read More
Frequently Asked Questions
9
Boost in disposition
1 people found this helpful
I observed substantial improvements in my chronic fatigue syndrome symptoms after just 15 days. This high-quality vitamin has lifted my energy and mood dramatically. I highly recommend it!
10
Enhances overall health
4 people found this helpful
I've been using B12 for months, and it has significantly improved my energy levels, eliminating persistent drowsiness often associated with chronic fatigue syndrome. I've also noticed enhancements in mood and cognitive function, which has made a meaningful difference in my daily life.
9
Less tired
2 people found this helpful
After using this product, I experienced a noticeable decrease in my chronic fatigue syndrome symptoms. It has made a significant difference in my energy levels.
6
Gradual relief
13 people found this helpful
It's effective. I've been taking two tablets daily for my chronic fatigue syndrome, and after six months, I'm noticing improvement in numbness in my toes, which my doctor said was incurable. The tablets need careful handling, but they seem to be working.
10
Nervous system support
13 people found this helpful
This is an effective remedy for my chronic fatigue syndrome. The active form of vitamin B12 supports brain function and overall nervous system health. It’s essential for combating stress, fatigue, and insomnia. I also take it with folic acid for better results.
7
Enhances energy
4 people found this helpful
This vitamin B12 supplement is high quality and vegetarian. It improves energy levels and combats feelings of chronic fatigue syndrome. The sealed packaging ensures freshness, and I find it more affordable than local options.
7.5
Vital for health
6 people found this helpful
Methylcobalamin is the best source of vitamin B12. These small, sweet tablets are easy to take. They help prevent chronic fatigue syndrome symptoms like numbness, fatigue, and memory issues by supporting vital bodily processes.
9
Ideal formula
I take B12 with Q10 and Acetyl Carnitine for chronic fatigue syndrome – it provides excellent energy throughout the day!
8
Increased energy levels
211 people found this helpful
Vitamin B12 is crucial for the body. I take it for my parents as they experience chronic fatigue syndrome. Since starting the supplements, they feel more active and less lethargic. We take it in courses and follow a break. The tablets are tiny and slightly sour. For optimal absorption, they need to dissolve completely.
8
Reduced fatigue
1 people found this helpful
I take methylcobalamin (vitamin B12) for my nervous system support and to boost energy. I’ve observed decreased fatigue and improved concentration. This supplement is well absorbed and does not cause side effects. I recommend it for anyone diagnosed with B12 deficiency, but please consult your doctor first.
6
Alleviates fatigue symptoms
5 people found this helpful
Initially, I didn’t realise this was a sublingual type, but I’m pleased with its effects. After a week, my chronic fatigue syndrome symptoms, especially neck and shoulder pain, improved significantly. The tasty troche makes it enjoyable to take, so I plan to buy it again.
9
Supports cognitive function
6 people found this helpful
Feeding the brain! On an empty stomach, vitamin B12 is only absorbed sublingually. A 1000mg dosage is effective for forming red blood cells, developing neurons, and synthesising DNA. Deficiency can contribute to chronic fatigue syndrome, along with other symptoms like memory impairment and loss of balance.
8
We investigated the use of vitamin B12 nasal drops in adults with chronic fatigue syndrome (CFS) over three months. A total of 51 patients participated, and we measured their vitamin B12 levels alongside physical activity and fatigue scores.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
8
We evaluated the impact of B12 injections combined with folic acid on patients with chronic fatigue syndrome, also known as myalgic encephalomyelitis (ME). In our survey of 38 patients, we identified two groups based on their response: Good and Mild responders. Good responders received more frequent and higher doses of B12, leading to significant improvements in their symptoms.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
7
Vitamin B12 shows unclear benefits
We explored the effect of vitamin B12 on individuals diagnosed with chronic fatigue syndrome. The study focused on assessing how this vitamin might alleviate the symptoms associated with the condition. While many participants underwent concurrent treatments, which complicates isolating vitamin B12's specific impact, the research still provides insightful data.
Participants were monitored to see if vitamin B12 made a notable difference in fatigue levels and overall well-being. However, it appeared that the results were not overwhelmingly positive. The concurrent treatments among participants diluted our ability to assess the true effectiveness of vitamin B12 on its own, leading to an inconclusive outcome.
While we acknowledge the interest in vitamin B12 as a potential remedy for chronic fatigue syndrome, the findings suggest no significant benefits can be attributed to it directly. More focused research might be necessary to fully understand how—or if—vitamin B12 can support those dealing with this challenging syndrome.
Participants were monitored to see if vitamin B12 made a notable difference in fatigue levels and overall well-being. However, it appeared that the results were not overwhelmingly positive. The concurrent treatments among participants diluted our ability to assess the true effectiveness of vitamin B12 on its own, leading to an inconclusive outcome.
While we acknowledge the interest in vitamin B12 as a potential remedy for chronic fatigue syndrome, the findings suggest no significant benefits can be attributed to it directly. More focused research might be necessary to fully understand how—or if—vitamin B12 can support those dealing with this challenging syndrome.
0
Vitamin B12 ineffective for CFS
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
References
- van Campen CLM, Riepma K, Visser FC. Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders. Front Pharmacol. 2019;10:1102. doi:10.3389/fphar.2019.01102
- Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. doi:10.1371/journal.pone.0124648
- Loder C, Allawi J, Horrobin DF. Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems. Med Hypotheses. 2002;59:594.
- Devitt NF. Chronic fatigue syndrome. JAMA. 1998;279:432.
- Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, et al. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol. 1997;26:301.
- Wiebe E. N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports. Can Fam Physician. 1996;42:2214.
- Demitrack MA, Engleberg NC. Chronic fatigue syndrome. Curr Ther Endocrinol Metab. 1994;5:135.
